The show, expected to be attended by about 7,000 users, begins today (11 May) in New Orleans, with SAP promising to make 15 major customer and product announcements.
The end of SAP R/3, which the company stopped selling earlier this year, will be on many delegates' agendas, said a SAP spokesman.
"There are going to be a number of presentations on R/3 which will discuss the roadmap for the future," he said. "A lot of the talk here will be from users who are moving to MySAP using our Netweaver integration platform."
The show's theme is "growth through innovation" - an attempt to show IT directors how to stop spending money on operations and invest in new technology.
"The dilemma facing most businesses is to grow without having any resources," the SAP spokesman said. "IT wants to help but most of its resource is tied up in day-to-day operations and integration projects.
"Using adaptive computing methods and Netweaver can help IT departments direct funds into innovation. There will be more than 40 presentations from customers explaining how they have done this."