RSA BSafe Crypto-C and BSafe Crypto-C Micro Edition will be tailored to take advantage of the 64-bit processing technology in the Opteron chip, allowing businesses to secure their applications developed for the Opteron.
AMD's Opteron processor is expected to be available by the middle of next year.
Developers use RSA's software to encrypt applications such as digitally signed forms, Internet messages and wireless communications.
AMD is trying to make migrating from current 32-bit server processors to its 64-bit technology as easy as possible for IT managers. The customised encryption software is designed to deliver performance benefits for encrypted applications that will run on the processor.
Sandia National Laboratories announced this week that it is building the fastest supercomputer in the US based on the Opteron processor.
RSA did not say when the software would be available.