The partnership combines Adobe's flash technology with Salesforce's Force.com platform to enable developers and IT departments to build and deploy enterprise applications.
These can be extensions and enhancements of existing Salesforce CRM implementations or new applications.
"Bringing together Adobe Flash and Force.com will enable the creation of exciting new kinds of business applications that run in the cloud," said Ariel Kelman, vice-president, platform marketing at Salesforce.com.
The cloud-based internet applications can be deployed to end-users via the browser though Adobe's Flash Player or directly to the desktop through Adobe AIR runtime environment software.
The new builder is integrated with Adobe LiveCycle Data Services that lets clients automatically synchronise data between the Force.com database and the Adobe AIR local data store.
This allows developers to build apps that connect between the browser and the desktop.
Analysts say the partnership is a coup for Adobe's Flash platform, which faces competition from Microsoft's Silverlight product.