Will Lewis, who was also in charge of the publisher's digital unit, has reportedly left the company.
Telegraph Media Group has not responded to Computer Weekly's requests for comment, but speculative versions of the reasons behind his departure include a disagreement with the company's chief executive over strategy and that Lewis and the publisher are parting ways in a "mutual agreement".
In November, Lewis was tasked with developing a new digital venture named 'Project Euston' while retaining his newspaper editor-in-chief title.
Project Euston aims at driving new revenue streams for the company. The venture was projected to have a staff of 50, of which 10 would be sourced within TMG, and "a budget north of £10m".
At the time of the project launch, the group's chief executive Murdoch MacLennan was quoted as saying that the new unit would "fast-forward to the next stage of our digital transformation".
In March, TMG announced a deal with Salesforce.com around the development of a crowd-sourcing website to report national opinion on the General Election.