In January, IT staff were warned in a letter that all sections of the department would be affected, according to a report in Computer Weekly's sister publication, Business and Technology.
The bank would not disclose a figure, but said where possible staff would be placed in other positions, helped to find a job outside the company, or offered voluntary redundancy. Once these measures have been taken, about 60 people will be made redundant, although the bank stressed a final figure had not been set.
A spokeswoman admitted that the bank was in discussions with the bank workers union Unifi to thrash out an acceptable plan.
"The whole structure of technology services is being reorganised and redesigned. Everyone's role is being reviewed to see how it will fit in," she said.
Last August, the bank said it wanted to implement a single IT system to run all its business divisions after admitting its IT costs were significantly higher than those of its competitors. At the time, the bank acknowledged that once underway, it would result in job losses.
Barclays insisted it must streamline operations and become more efficient if it is to fight off competition from traditional rivals and new entrants into the market.
A Unifi spokesman said the union was satisfied with the progress of negotiations.