The Fujitsu Services site handles a number of IT outsourcing contracts for large companies and government departments. The dispute is over employee benefits and union rights.
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The union held a strike earlier this month, and took a day’s strike action last year after the dispute began in November
The latest action will take place from Monday 29 January to Friday 2 February.
The union plans to send strikers to other Fujitsu sites around the country to help gain support from other workers and collect money for their campaign.
It is not known how the dispute has so far affected the Fujitsu Services contracts at the Manchester plant, which include one for Marks & Spencer.