Elements of the proposed settlement, announced in the US on 2 November, could affect the European probe of Microsoft, but Commission spokeswoman Amelia Torres claims it is too early to tell.
"There might be certain features in the US settlement which might or might not have an impact on the Commission's own investigation involving Microsoft," she said.
While Microsoft realised that a settlement in the US lawsuit would not end its case in Europe, the company said it hoped to settle with the Commission as well.
"We would like to appropriately settle the matter with the European Commission," said Microsoft president and chief executive officer Steve Ballmer.
The European Commission is investigating whether Microsoft violated European rules to extend its position in the market for low-end server operating systems by using its dominant position in PC operating systems. It is also examining Microsoft's software bundling tactics, focusing particularly on Windows Media Player.