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A survey of education and skills by the CBI found 69% of employers think promoting science and maths in schools should be the government's top priority, while 67% think firms can encourage STEM study by engaging with schools.
With nearly 100,000 students only achieving a grade 'F' or below in mathematics this year, CBI director-general Richard Lambert warned too few students are studying STEM subjects, restricting career opportunities later in life.
"Far too few students are given the option by schools to do triple science, and too few are taking it up even if it's available. Pupils, parents and teachers should know that triple science offers the best preparation for A-level science and a whole range of careers," he said.
"No-one wants gifted young people to miss out on future opportunities because they leave science behind at GCSE."
High quality, impartial careers advice needs to signpost where there is growing employer demand for young students, said the CBI.
Read more about GCSE results: