Ian Carruthers, acting chief executive of the NHS, has been appointed overall senior responsible owner for the £6.2bn national programme for IT in the NHS.
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Carruthers has taken over from John Bacon, who stepped down following his departure from the Department of Health earlier this year.
In 2004, Bacon, the department's director of delivery, was also appointed chairman of the national IT programme board. In July 2005, he became overall SRO for the programme.
Richard Granger remains SRO for programme and system delivery, and Richard Jeavons is SRO for service implementation.
Carruthers is the most senior department official to take charge of the programme. His appointment follows several changes in the top management of the programme since it began in 2003.
Aidan Halligan stood down as SRO for clinician engagement in 2004, six months after taking the post. The first SRO of the NPfIT was John Pattison, who retired.