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But users of the platform have been warned against making sudden migration plans, even though HP only plans to ship the hardware for a further three years.
Alphaservers running OpenVMS are typically used for mission-critical applications in areas such as banking, aerospace and manufacturing.
Martin Riley, HP's Alphaserver business manager for UK and Ireland, said, "Because of their mission-critical applications, customers cannot switch overnight - it will take them years of planning."
The company has pledged to support the Alphaserver range until 2012 and users will be able to run OpenVMS on the machines until about 2022.
Colin Butcher, board member of the HP User Group, said, "There is so much at stake that you do not want to risk the disruption. Moving platforms in an operational mission-critical environment should only be done after careful and thorough testing."
But Butcher urged users to get involved with HP's early adopters programme to gain experience of the new platform. A developer's kit to enable users to examine OpenVMS on Integrity servers will be available in December.