Hunt was in charge of delivering the Department of Health's IT strategy, Delivering 21st Century Support, which included major national projects including a national patient booking system, electronic health records and electronic reporting of laboratory results.
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Ewan Davis, vice chair of the British Computer Society - Primary Health Care specialist group, said Hunt's resignation "is a loss" for NHS IT.
"People may have been critical of the government's NHS IT strategy, but Hunt had a better chance of leading it to success than someone without his healthcare experience," said Davis.
Paul Goss, director of health IT analyst group Silicon Bridge Research, said, "Lord Hunt was a good bridge between the health service and policy makers in Westminster and Whitehall."
Hunt's resignation was unlikely to have a fundamental long-term impact on the £5bn NHS IT programme, said Goss. "The programme is already under way. The money is allocated. Richard Granger [NHS national IT programme director] is kicking things off."Goss pointed to the recent decision to appoint a director of delivery within the Department of Health as a sign that long-term planning mechanisms were in place to ensure the success of the NHS IT investment.