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Supply chain software company i2 Technologies is making up to 15% of its 2,000 staff redundant in an attempt to return to profitability.
The move is designed to reduce quarterly operating expenses to below $70m (£39m), compared with $85m in the fourth quarter of 2004.
As part of the staff cuts the company expects to incur a restructuring charge in the first quarter of 2005.
The cuts would affect most business units and regions, said i2.