Karen Francis, 39, a vice-president, will become a consultant to Ford on e-commerce activities and "pursue other opportunities", the company said.
Ford last month dissolved a joint venture with Qualcomm to develop in-vehicle communications devices and services. Last year, it pulled the plug on a programme to provide all employees with computers and Internet access.
Francis's resignation follows the resignation last month of Kevin English, chief executive officer of the online automotive marketplace Covisint.
DaimlerChrysler, Ford Motor, General Motors, Nissan, Renault, Commerce One and Oracle back Covisint, but resistance from tier one and tier two suppliers meant it failed to live up to initial expectations on trading volumes.