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The vendor has reorgainsed around four areas: endpoint security, network security, content security and risk and compliance.
The decision to make the changes has been described as a reaction to the different threat landscape in the market as well as a move from users away from point products.
"Businesses are looking for solutions to business issues, not just point products," said Dave DeWalt, president and CEO of McAfee.
"By aligning with these business issues, and providing a comprehensive approach that includes products, technology and delivery methods, we aim to provide the best customer experience," he added.
Endpoint security will be headed by Candance Worley and include anti-virus, anti-spyware, anti-spam, web security, desktop firewall, intrusion prevention, network access control (NAC), policy auditing and encryption to properly defend a business from threats and increased regulation.
Network security is headed by Rees Johnson and includes the vendor's next generation firewall and application identity and control.
Content security, which focuses on email, web and data loss prevention is going to be run by Marc Olesen.
Finally risk and compliance, which is becoming increasingly important, will be run by Stuart McClure.