Sussex Health Informatics Service (HIS), which provides IT services to all 11 NHS trusts in the Sussex region, is deploying consolidated Sophos security and management solutions to protect 25,000 users.
The roll-out, which is due for completion this month, will replace a range of disparate systems from different suppliers, including McAfee, Symantec and Trend Micro.
The aim is to streamline security efficiency and reduce costs, while increasing functionality and raising defences.
"Steve Orman, head of IT at Sussex HIS, said "consolidating the IT security of 11 separate trusts is a tall order."
Sophos Endpoint Security and Control, which combines anti-virus protection with a client firewall, is being deployed to protect Sussex NHS trusts' desktops against viruses, Trojans, worms, spyware, adware, potentially unwanted applications (PUAs) and hackers.
Additionally, Sophos Email Security and Control will protect the trusts against spam and email-borne malware, scanning all inbound, outbound and internal messages at the email gateway before they can enter the network.
The trusts will also benefit from the added security of Sophos' Behavioural Genotype Protection - a proactive intrusion prevention technology that combats zero-day Windows attacks, and automatically guards against new and targeted threats by analysing behaviour before code executes.
Sussex HIS will undertake the day-to-day running of the new security system, backed up by Sophos' 24/7 Platinum support services.