The job losses had been expected after the retailer's £590m acquisition of GUS Catalogues earlier this year.
"Currently there are 360 IT employees and we will reduce this headcount by 60 before the end of the year. Wherever possible we will seek to achieve losses on a voluntary basis," a Littlewoods spokeswoman said.
"Littlewoods has benefited from a period of substantial investment in IT in order to deliver key projects to support and improve the infrastructure of the business. As these projects have now been delivered, it is appropriate to refocus the business area."
In March, Littlewoods revealed it was cutting 66 jobs in its central IT department as a result of the split between its home shopping and high street divisions following its takeover by the Barclay Brothers.
The company said it had no plans for more IT redundancies.