Boots is set to be the first high street retailer to trial a contactless payment system.
The chemist is working with MasterCard to introduce a system that will allow customers to pay amounts under £10 by touching their MasterCard PayPass cards against terminals, without having to enter a PIN.
Fifteen stores in London and six in Liverpool will trial the technology in the second half of this year.
Boots says it is too early to say whether the system will be rolled out nationally if the trials are successful.
A spokesperson said, "We are always looking for ways to make shopping more convenient in our stores."
Barclaycard has led the rollout of the technology, which is growing across the UK, with contracts to provide the service at Pret A Manger, EAT, Yo! Sushi and Coffee Republic.
The company says it "welcomes" the contract between Boots and Mastercard, but it was quick to release a statement pointing out it has "the highest market share of contactless terminals in the UK".
Mobile phones with the technology embedded in them will be on the mass market by 2012, it added.