The move bucks the recent trend, which has seen UK IT workers losing out to their Indian counterparts on software programming and operations jobs.
GTL, a telecoms infrastructure provider, BPL Telecom, a mobile phone operator, Infrasoft Technologies, a financial software supplier and Elan, a laser technology specialist, will establish operations across Wales in the next few months.
A further 30 Indian companies from various technology sectors have shown an interest in similar commitments, the Welsh Development Agency said last week.
Hilary Hendy, international executive director at the development agency, said the Indian initiative is proving a worthwhile investment of Welsh resources. "More technology companies in India want to internationalise their activities.
"So far these companies have been targeting the London area to start up in the UK or Europe," she said.
The initial projects would create up to 300 new jobs in the area, the development agency said.